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Welcome to the UK Clinical Trials Gateway

Our site is here to help you find out about health and social care research that is taking place across the UK.

You can find out what 'clinical trials' and 'health and social care research' involves as well as finding out about studies that are happening right now into any condition or disease area.

The NIHR has a new visual identity to better reflect the breadth of its work. To find out more, please visit the NIHR website.

Latest research findings

from the NIHR Dissemination Centre

Honey may help painful mouth inflammation caused by cancer treatments
Compared to usual care, honey was more likely to reduce moderate or severe pain for patients after radiotherapy and/or chemotherapy treatment. This systematic review looked at trials from around the world comparing different types of honey with other treatments such as chamomile, golden syrup or placebo. The main outcome was the onset of moderately severe oral mucositis as measured by a range of standardised assessment scales. The findings suggest that honey might be useful, although whether the type of honey used makes a difference is uncertain. It may be prudent to choose sterilised medical honey, rather than raw natural honey, in people with reduced immunity. Possible biases in the underlying studies make it is difficult to know how certain we can be in the review’s estimates of an effect. As most trials of honey seemed to show an improvement compared to their comparator treatments, better quality research seems justified.
19 February 2019

A commonly-used antidepressant doesn’t improve recovery after stroke
The antidepressant fluoxetine works no better than placebo to reduce disability after a stroke, lowering hopes that had been raised by other smaller studies. After a six month trial including more than 3,000 adult stroke patients recruited at 103 UK hospitals, researchers concluded that fluoxetine should not be used to promote recovery from stroke-related disability, or routinely prescribed to prevent depression after stroke. Several smaller studies and animal trials had found promising results from the use of fluoxetine after stroke. However, this trial of fluoxetine 20mg daily for six months found no improvement in function among those taking the drug. Although people who took fluoxetine were less likely to get depression, they were more likely to have fractures. Other studies of fluoxetine after stroke are underway, but this trial does not support using it in standard post-stroke care.
12 February 2019

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