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Welcome to the UK Clinical Trials Gateway

Thank you for visiting the UK Clinical Trials Gateway. We hope it gives you a clear understanding of what is involved if you participate in a clinical trial. You can search this site in various ways to find trials relevant to you and contact researchers yourself.

But, before doing any of this, you may have questions about trials, what they are and how they work. Indeed, you may have come to this site because your doctor has invited you to join a trial but you want to know more before you decide.

Taking part in medical research is a big step. It can potentially deliver great benefits to you or a loved one but it may also involve some inconvenience or risk. This site includes plenty of information about what a trial involves and what you can expect if you take part (more here).

We hope the general information about trials is useful. You may find that individual trial records contain complex scientific and medical terms and are hard to understand. We are working to address this (more here) and hope that you are able to find out what you need from the contact named on the trial record or from your own doctor.

We continue to introduce and test new features on the site and welcome your feedback and comments.If you have any general questions about the UKCTG website or suggestions about how we can improve it, please feel free to contact us at ukctg@nihr.ac.uk.


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Latest research findings


from the NIHR Dissemination Centre

Individual support of nurses using electronic medicine monitors can improve HIV treatment
Use of electronic pill bottles that record when they are opened and follow-up discussion of the printed readouts with nurses improved HIV outcomes. It is thought that patients became more reliable in taking the medication, which can have complicated scheduling. Overall, the HIV virus in the blood and the risk of treatment failure were lower in the group of patients who had access to this intervention compared to regular care. In addition to being more effective, the programme also reduced the estimated lifetime cost and disease burden per patient, considering quality and quantity of life lived. The readouts were used to help focus attention on any patterns of medication usage so that strategies could be discussed to improve adherence. As non-adherence is the main barrier to effective management of HIV, any measures that improve it are welcomed. However, the intervention tested here requires several hours of training for the nurses delivering it and may not be that easy to introduce in practice. Evaluation of the approach in non-trial settings is necessary before wider implementation.
10 October 2017

Early discharge ‘hospital-at-home’ gives similar outcomes to in-patient care
Supported early discharge, where patients receive on-going hospital-level treatment in their own home, had no effect on mortality compared with standard in-patient care. Patients had shorter hospital stays, were more likely to be satisfied and less likely to end up in residential care. This updated Cochrane review identified 32 international trials comparing early discharge hospital-at-home with hospital in-patient care. Most evidence related to people recovering from a stroke, where NICE already recommends supported discharge if this is appropriate. Other patient groups included those recovering from orthopaedic surgery and older people with various conditions. Trials were relatively small and the overall evidence quality was moderate to low. The review aimed to see whether early discharge has an effect on NHS costs, but found insufficient evidence. Training, staffing and equipment costs need to be measured against patient outcomes in different therapy areas. Early supported discharge needs to be driven in areas where it can make the most difference and give the greatest benefit.
03 October 2017

Head position after acute stroke does not affect disability outcomes
Lying flat for 24 hours after a stroke is no better than sitting up at an angle of at least 30 degrees. These differences in early head position did not affect people’s levels of disability or survival to 90 days, which was more than 92% in both groups. It had been thought that the head down position might increase the chance of pneumonia, but in this trial, the rates were also similar for people cared for in either position. The results of this large international randomised controlled trial are likely to be applicable to adults with different types of stroke in varied settings. As lying position did not affect outcomes, this suggests that clinicians can be guided by patients’ clinical condition, preferences and levels of comfort during the initial management of care. The current NICE guideline on diagnosis and initial management of stroke suggests that people with acute stroke should be helped to sit up as soon as possible (when their clinical condition permits).
03 October 2017

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Better healthcare starts with you

The UK Clinical Trials Gateway is designed to help you participate in clinical trials running in the UK.

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