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Welcome to the UK Clinical Trials Gateway

Thank you for visiting the UK Clinical Trials Gateway. We hope it gives you a clear understanding of what is involved if you participate in a clinical trial. If you decide to sign up so that researchers can contact you about trials that might be suitable, you can do so here. You can also search this site in various ways to find trials relevant to you and contact researchers yourself.

But, before doing any of this, you may have questions about trials, what they are and how they work. Indeed, you may have come to this site because your doctor has invited you to join a trial but you want to know more before you decide.

Taking part in medical research is a big step. It can potentially deliver great benefits to you or a loved one but it may also involve some inconvenience or risk. This site includes plenty of information about what a trial involves and what you can expect if you take part (more here).

We hope the general information about trials is useful. You may find that individual trial records contain complex scientific and medical terms and are hard to understand. We are working to address this (more here) and hope that you are able to find out what you need from the contact named on the trial record or from your own doctor.

We continue to introduce and test new features on the site and welcome your feedback and comments.If you have any general questions about the UKCTG website or suggestions about how we can improve it, please feel free to contact us at ukctg@nihr.ac.uk.


Find trials near you.


Click on a location to see the trials running.


Latest research findings


from the NIHR Dissemination Centre

Intensive speech therapy helps stroke survivors with persistent communication difficulties
Intensive speech and language therapy begun six months or more after a stroke improved verbal communication, language comprehension and self-reported quality of life for those with persistent communication difficulties (chronic aphasia). The therapy in this trial consisted of around 30 hours over three weeks. Participants who received low-intensity therapy (around one hour per week) whilst on a waiting list did not improve during that time. NICE guidelines recommend speech and language therapy immediately after a stroke and if the person still experiences communication difficulties six months after their stroke, but do not specify the intensity of the therapy. This trial highlights the modest benefits of providing further intensive speech and language therapy for stroke survivors who continue to have aphasia after six months. The Royal College of Speech and Language Therapists previously raised concerns about lack of access to this type of therapy. However before implementation it will be important to know which component of therapy is providing the benefits and how much it costs compared to alternatives.
18 July 2017

Screen reminders for GPs did not improve anticoagulant prescribing in atrial fibrillation
General practice software that generated screen reminders for patients with atrial fibrillation did not increase the proportion taking oral anticoagulants appropriately by six months. This NIHR-funded trial included GPs in 47 surgeries in England and found that at the start only 63% of eligible patients with atrial fibrillation were being prescribed anticoagulants. Six months later the rate had increased to 66% in intervention practices and 64% in those following usual practice, a non-significant difference between the groups. Use of the software was associated with increased diagnosis of transient ischemic attack, which could be due to improved detection or over-diagnosis. A reduction in strokes of any type was of borderline statistical significance after 12 months. Longer term studies, collecting more detail on anticoagulant prescribing and the reasons behind patient and doctor choices, may support practice improvements in the future.
18 July 2017

Online education, pain coaching and advice by video conference can reduce knee pain
For people with chronic knee pain from osteoarthritis, a programme including online education, interactive pain coaching and physiotherapy advice from a professional by skype gave greater improvement in pain and function at nine months than online education alone. The small randomised control trial included 148 adults aged 50 or over in Australia. Clinically meaningful improvements in pain and physical function were achieved by around three-quarters of the comprehensive intervention group compared with just under half receiving education alone. Internet-delivered treatment could increase access, reduce clinician face-to-face time, and in the long-term reduce the need for knee replacement surgery, if found to be cost-effective. However, only competent users of information technology with access to the internet would be able to receive treatment in this way. Therefore, it might not be an effective alternative for everyone compared with in-person appointments with the GP or physiotherapist.
18 July 2017

More research news on clinical trials

Better healthcare starts with you

The UK Clinical Trials Gateway is designed to help you participate in clinical trials running in the UK.

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