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Welcome to the UK Clinical Trials Gateway

Thank you for visiting the UK Clinical Trials Gateway. We hope it gives you a clear understanding of what is involved if you participate in a clinical trial. You can search this site in various ways to find trials relevant to you and contact researchers yourself.

But, before doing any of this, you may have questions about trials, what they are and how they work. Indeed, you may have come to this site because your doctor has invited you to join a trial but you want to know more before you decide.

Taking part in medical research is a big step. It can potentially deliver great benefits to you or a loved one but it may also involve some inconvenience or risk. This site includes plenty of information about what a trial involves and what you can expect if you take part (more here).

We hope the general information about trials is useful. You may find that individual trial records contain complex scientific and medical terms and are hard to understand. We are working to address this (more here) and hope that you are able to find out what you need from the contact named on the trial record or from your own doctor.

We continue to introduce and test new features on the site and welcome your feedback and comments.If you have any general questions about the UKCTG website or suggestions about how we can improve it, please feel free to contact us at ukctg@nihr.ac.uk.


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Click on a location to see the trials running.


Latest research findings


from the NIHR Dissemination Centre

Two common operations to fix a broken tibia have similar outcomes
In people who had broken the lower part of their tibia (shin bone), fixation using a metal rod nailed to the insideof the bone was compared with a locking plate screwed onto the surface of the bone. There was no difference in the quality of life, disability or pain at 12 months for people who had fractures of the lower tibia fixed using either technique. NICE guidance recommends that surgery takes place within 24 hours of injury but does not mandate which type of surgery to perform. This NIHR UK-based trial was funded to find which treatment was better for lower tibial fractures. During the trial, some people expressed a preference for one operation over the other and surgeons were generally more in favour of the nail fixation. The findings suggest that surgeons should continue using their judgement to decide which surgical approach is best, in discussion with the patient.
16 January 2018

Blood test reduces mortality and shortens antibiotic use among adults with chest infection
It may be feasible to use procalcitonin blood levels to guide antibiotic treatment for adults in hospital with a suspected chest infection. By measuring procalcitonin, an indicator of bacterial infection, clinicians could review their diagnosis earlier. This reduced antibiotic exposure by 2.5 days with fewer adverse effects and also less mortality. About 14 extra people in every 1,000 who had their management guided by the blood test would be expected to survive the first month, compared with those receiving standard care without this test. Antibiotics are commonly prescribed pre-emptively for a suspected respiratory infection and may be continued longer than necessary. As blood procalcitonin levels increase in response to bacterial infection, procalcitonin may have potential to guide starting or stopping antibiotics. This NIHR-funded review adds 18 trials to the growing body of evidence indicating that procalcitonin may help refine the use of antibiotics in select patient groups.
16 January 2018

Giving oxygen routinely after a stroke does not improve outcomes
There was no benefit to routinely giving oxygen to people who have had a stroke. Oxygen given continuously, or just overnight, did not reduce disability or death and it did not improve people’s ability to do everyday tasks or live independently. There were no oxygen-related adverse events reported. Strokes occur when the blood supply to the brain is disrupted by either a blocked or burst blood vessel. They can lead to death or disability as parts of the brain are deprived of blood. Therefore, giving oxygen to reduce the potential damage may appear to make sense. Guidelines from NICE and the British Thoracic Society recommend that people are not routinely given oxygen after a stroke unless their oxygen levels drop. This large NIHR funded trial provides evidence to support these recommendations and reinforces the need to monitor oxygen levels to guide the appropriate use of oxygen therapy on an individual basis. Given the size and quality of this UK-based trial, it is unlikely that future research would change these recommendations.
03 January 2018

More research news on clinical trials

Better healthcare starts with you

The UK Clinical Trials Gateway is designed to help you participate in clinical trials running in the UK.

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